Preparation of Non-Toxic Fluorescent Peptide-Coated Silica/PEG Nanoparticles from Peptide-Block Copolymer Conjugates

Peptide-decorated nanosystems have demonstrated higher stability and improved cellular uptake as compared to bare NPs appear highly promising in diagnostics theranostics of cancer. Herein, we discuss the preparation structural characterization peptide-functionalized silica/PEG NPs, starting from peptide–block copolymers, prepared turn by conjugation peptides block copolymers before NP formation. This synthetic design allowed full control density composition peptide surface coverage. Preliminary experiments support low toxicity fluorescent peptide–NPs their ability cell internalization.